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KMID : 0614620090530040216
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Korean Journal of Gastroenterology
2009 Volume.53 No. 4 p.216 ~ p.220
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Enhanced Chemotherapeutic Drug Delivery to Tumor Tissue by High Intensity Focused Ultrasound
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Jung Jin-Tae
Lee Don-Haeng
Hwang Joo-Ha
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Abstract
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Cancer is the first leading cause of death in Korea. Systemic chemotherapy is currently the standard treatment for a wide variety of cancers; however, in the majority of cases, cure is not achieved, and the attendant side effects of the treatment are considerable. The effectiveness of chemotherapy in cancers depends on the adequate delivery of the chemotherapeutic agent to cancer cells. The achievement of uniform drug delivery of chemotherapeutic agents throughout tumors is limited by the anomalous vascularization and blood vessel permeability. Ultrasound has an ever-increasing role in the delivery of therapeutic agents including chemotherapeutic agents, proteins, and genetic materials. Ultrasound technology allows for the use of focused ultrasound energy for therapeutic purposes by delivering high-intensity focused ultrasound for applications such as tissue ablation, and enhanced drug delivery. We reviewed recent work in the emerging field of ultrasound-based therapeutics, with particular emphasis on the delivery of drugs to tumor tissue.
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KEYWORD
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High intensity focused ultrasound, Chemotherapeutic agent, Drug delivery
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